digital twins & systems thinking
- Thinking in Systems — Donella Meadows
- Complex Adaptive Systems (intro-style resources)
healthcare + biomedical data
- Deep Medicine — Eric Topol
- The Patient Will See You Now — Eric Topol
- Fundamentals of Clinical Data Science (any strong clinical DS text)
ML/AI
- Deep Learning — Goodfellow et al.
- Designing Machine Learning Systems — Chip Huyen
drug discovery / longevity
- Drug discovery ML surveys + geroscience reviews (see papers below)
sales + marketing (for health-tech builders)
- Traction — Gabriel Weinberg
- Crossing the Chasm — Geoffrey Moore
- Influence — Robert Cialdini
github repos (curated)
digital twins
- edt-community/awesome-digital-twins — great map of the ecosystem
- eclipse-ditto/ditto — digital twin pattern for connected devices
- Azure-Samples/digital-twins-explorer — visualize/manage twin graphs
human digital twin foundations
- BioGearsEngine/core — open-source human physiology engine
- opencor/opencor — CellML simulation environment
- opensim-org/opensim-core — musculoskeletal simulation engine
- SimVascular/SimVascular — patient-specific blood flow modeling
- MarekMatejak/Physiolibrary — Modelica human physiology building blocks
- ComputationalPhysiology/awesome — computational physiology index
wearables + biosignal processing
- neuropsychology/NeuroKit — NeuroKit2 biosignal processing
- paulvangentcom/heartrate_analysis_python — PPG/ECG heart rate + HRV
- MIT-LCP/wfdb-python — PhysioNet/WFDB waveform tooling
- mne-tools/mne-python — EEG/MEG analysis
- woop/awesome-quantified-self — wearables + quantified self landscape
health data standards
- openmhealth/schemas — wearable/health measurement schemas
- hapifhir/hapi-fhir — FHIR server/client
- OHDSI OMOP CDM — standardized observational health data model
healthcare ML
- sunlabuiuc/PyHealth — healthcare ML toolkit
- josephmisiti/awesome-machine-learning — broad ML index
- danielecook/Awesome-Bioinformatics — bioinformatics software index
drug discovery + computational chemistry
- DeepChem — drug discovery ML toolkit
- RDKit — cheminformatics foundation
- OpenMM — molecular simulation toolkit
- DiffDock — deep-learning docking
- Awesome-GNN-based-drug-discovery — GNN drug discovery tools
knowledge graphs + biomedical ontologies
- Hetionet — biomedical network for repurposing-style reasoning
- Biolink Model — schema layer for biomedical KG interoperability
- Monarch Initiative — KG + phenotype/genotype integration ecosystem
real-time health visualization
- grafana/grafana — dashboards + observability UI
- influxdata/influxdb — time-series datastore
- timescale/timescaledb — Postgres time-series analytics
- apache/kafka — streaming backbone for sensor pipelines
research articles
digital twins in healthcare
- Digital Twins' Advancements and Applications in Healthcare (PMC review)
- A scoping review of human digital twins in healthcare (npj Digital Medicine)
- Digital twins in healthcare: a comprehensive review (Frontiers, 2025)
- A comprehensive review of digital twin in healthcare (PMC, 2025)
longevity / geroscience
- Hallmarks of aging: An expanding universe (2023)
- From geroscience to precision geromedicine (Cell, 2025)